Relationship of the Pro12Ala Polymorphism on the PPARy2 Gene With the Body Composition of Practitioners of Cyclic Exercises.

This study aimed to verify the association between the genotypic of the receptor gene activated by peroxisome proliferators gamma 2 (PPARy2) and the body composition and the specific indicators of adiposity in practitioners physical exercises, considering nutritional intake, age, and training load as influencing factors. It was conducted a cross-sectional study with 335 adults (47.9 ± 12.7 years, 138 men, body mass index/BMI = 27.0 ± 4.9 kg/m2), practitioners of aerobic exercises in cyclical modalities (running, walking and/or cycling, who spent 328.3 ± 193.6 kcal/day on physical training). The genotyping of the Pro12Ala polymorphism was performed using the PCR-RFLP technique and the body composition measured by bioimpedance (InBody 720). Energy expenditure was based on the compendium of physical activities and caloric intake was measured by 24 h recall questionnaire. The higher prevalence was for the Pro/Pro genotype (76.1% vs. 23.9% of Pro/Ala). Pro/Pro genotypic group showed significant higher mean values for body mass (BM) (p < 0.03 for men and p < 0.02 for women) and BMI (p < 0.00 for men and p < 0.02 for women) and %FAT (p < 0.00), waist-hip ratio (WHR) (p < 0.04), and visceral fat (VF) (p < 0.00) only in men compared to Pro/Ala. Higher frequency of Pro/Pro was observed in the category indicating BMI (p < 0.00 for men and p < 0.03 for women), WRH (p < 0.03 for men and p < 0.00 for women), and %FAT (p < 0.03) (in the latter case, only among men. It was also observed that the frequency of distribution of Pro/Ala in the eutrophic category of the BMI remained independent of all influencers, while WHR and %FAT were independent of the training load, but influenced by nutritional intake and age. In women, the frequency of Pro/Ala distribution at the lowest BMI and WHR values remained independent of all confounding variables. It is concluded that the Pro12Ala polymorphism in the PPARy2 gene consistently influences indicators of body composition and adiposity, regardless of the practitioners of physical training, but the relationship needs to be considered according to age and nutritional intake.

Relação entre Comportamento Glicêmico eLactacidêmico no Exercício Resistido / Relationship Between Glycemic and Lactacidemic Behavior in the Resistance Exercise

Investigar a relação entre o comportamentoglicêmico e a produção de lactato no exercício demusculação. Material e Métodos: Cinco homens (18 e 25anos), realizaram dois treinamentos com três séries de 10exercícios para membros inferiores, com intensidade elevada(SI), utilizando-se 08 a 12 repetições máximas; e moderada(SM), com cargas equivalentes a 50% da utilizada em SI.Coletas sanguíneas foram tomadas antes e ao final de cadadois exercícios. As concentrações séricas de lactato eglicemia foram feitas em analisadores portáteis. Os dadosforam tratados pelo teste de Wilcoxon e pela correlação deSpearman (p< 0,05). Resultados: Em SI, a glicemia mostrousesempre mais elevada (98, 93.4, 100, 103 e 104 mg/dl) queem SM (95.6, 90.6, 93.8, 90.2 e 92.4 mg/dl), com p<0,05 nosdois últimos exercícios. Os maiores valores glicêmicos foramacompanhados de concentrações séricas de lactato maiselevadas em SI (7.08, 8.40, 9.12, 7.66, 8.82 mM), comparadocom SM (6.12, 7.54, 6.06, 5.22 e 6.70 mM), com p<0,05 nastrês últimas medidas. Observou-se correlação entre lactatoe glicemia em SI (r2= 0,839) e SM (R2= 0,873), indicandorelação de causa e efeito entre lactacidemia e glicemia.Conclusão: A maior produção de lactato em exercícios dealta intensidade pode ser entendido como um dos fatoresenvolvidos nos maiores valores glicêmicos encontradosnestes exercícios...

To Investigate the relationship between behaviorglycemic and lactate production in the resistance training.Material and methods: Five males (age 18 to 25), performedtwo sessions with three series of 10 exercises for the lowerlimbs, with intensity high (SI), using 08 to 12 maximalrepetitions; and moderate (SM), with loads equivalent to 50%of SI. Blood samples were taken before and at the end ofevery two exercises. The serum concentrations of lactateand glucose were made in portable analyzers. The Datawere treated by the Wilcoxon test and by Spearman’scorrelation (p<0.05). Results: In SI, glycemia was alwayshigher (98, 93.4, 100, 103 and 104 mg/dl) that SM (95.6, 90.6,93.8, 90.2 and 92.4 mg/dl), with p<0.05 in the last twoexercises. The highest glycemic values were accompaniedby serum higher concentrations of lactate in SI (7.08, 8.40,9.12, 7.66, 8.82 mM), compared with SM (6.12, 7.54, 6.06,5.22 and 6.70 mM), with p<0.05 in the last three measures. Itwas observed correlation between lactate and glycemia inboth SI (r2= 0.839) and SM (r2= 0.873), indicating a cause -effect relationship between lactacidemia and glycemia.Conclusion: The greater lactate production in exercises ofthe high intensity may be understood as one of the factorsinvolved in the largest glycemic values encountered in theseexercises...